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Microfluidics in Assessing Platelet Function

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Lipaemic donations: truth and consequences.

Giuseppe Lippi¹, Massimo Franchini

¹Unità Operativa di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis

|November 27, 2012

Summary

This summary is machine-generated.

Using turbid plasma from lipaemic donations for blood components poses significant challenges in transfusion medicine. Harmonizing global policies is crucial for addressing these issues and ensuring blood product safety.

Keywords:

Hypertriglyceridemia Interference Lipaemia Patient safety Transfusion medicine

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Area of Science:

Transfusion Medicine
Blood Component Production
Clinical Pathology

Background:

Lipaemic donations, characterized by turbid plasma, present challenges due to epidemiological, technical, analytical, clinical, and economic factors.
Guidelines generally advise against using lipaemic donations for blood components, stemming from causes like metabolic disorders, diseases, and drug use.
The frequency of lipaemic donations varies significantly, from 0.31% to potentially 13% in sporadic cases.

Purpose of the Study:

To highlight the significant issues associated with using lipaemic donations in transfusion medicine.
To underscore the unresolved questions regarding the clinical use of blood components derived from lipaemic materials.
To advocate for a global consensus and harmonization of policies concerning lipaemic donations.

Main Methods:

Review of existing guidelines and literature on lipaemic donations.
Analysis of the challenges posed by turbid plasma in blood component production.
Discussion of the implications for laboratory testing and product safety.

Main Results:

Lipaemic donations interfere with laboratory testing, though methods exist to mitigate this.
The safety and clinical utility of blood components derived from hypertriglyceridaemic materials remain a critical, unresolved issue.
Current policies on handling lipaemic donations lack global uniformity.

Conclusions:

Addressing the challenges of lipaemic donations requires a unified approach in transfusion medicine.
Further research and collaboration are needed to establish standardized protocols for lipaemic blood utilization.
Harmonizing international policies is essential for ensuring the safety and efficacy of blood components derived from potentially lipaemic donations.