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Fungal infection and increased mortality in patients with chronic granulomatous disease

S Bassiri-Jahromi1, A Doostkam

  • 1Medical Mycology Department, Pasteur Institute of Iran, Pasteur Street, number 69, P.O. Box: 1316943551, Tehran, Iran. basiri@pasteur.ac.ir

Journal De Mycologie Medicale
|November 27, 2012
PubMed
Abstract

Insights

Fungal infections are a significant threat to individuals with chronic granulomatous disease (CGD), often affecting the lungs and bones. This study highlights Aspergillus and Fusarium as common culprits, emphasizing the need for vigilance in CGD patient care.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Medical Mycology

Background:

  • Chronic granulomatous disease (CGD) is a primary immunodeficiency predisposing patients to severe bacterial and fungal infections.
  • Individuals with compromised immune systems, including CGD patients, face heightened risks from opportunistic fungal pathogens.

Purpose of the Study:

  • To determine the incidence of fungal infections in CGD patients.
  • To identify prevalent fungal pathogens causing infections in this population.
  • To ascertain risk factors for fungal infections and associated mortality in CGD.

Main Methods:

  • Retrospective review of 12 CGD patients diagnosed between 1995 and 2008.
  • Diagnostic confirmation of fungal infections through histopathology, direct preparation, culture, and radiological examination.
  • Data collection from medical records of patients with suspected fungal infections.

Main Results:

  • Fungal infections were confirmed in 41.7% of the evaluated CGD patients.
  • Aspergillus spp. and Fusarium spp. were the most frequently isolated fungal pathogens.
  • Common manifestations included osteomyelitis (42.8%), pulmonary infections (28.6%), lymphadenopathy (14.3%), and skin involvement (14.3%).

Conclusions:

  • Invasive fungal infections represent a frequent and life-threatening complication in CGD.
  • The lungs and skeletal system are the most commonly affected sites, though lymphatic and skin involvement also occur.
  • Fusariosis is identified as a significant threat to CGD patients, necessitating targeted diagnostic and therapeutic approaches.

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