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Updated: May 16, 2026

Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea
Published on: January 1, 2016
Changes in the adult vertebrate auditory sensory epithelium after trauma
1Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology-Head and Neck Surgery, CHDD CD176, Box 357923, Univ. of Washington, Seattle, WA 98195-7923, USA. oesterle@uw.edu
Abstract:
Auditory hair cells transduce sound vibrations into membrane potential changes, ultimately leading to changes in neuronal firing and sound perception. This review provides an overview of the characteristics and repair capabilities of traumatized auditory sensory epithelium in the adult vertebrate ear. Injured mammalian auditory epithelium repairs itself by forming permanent scars but is unable to regenerate replacement hair cells. In contrast, injured non-mammalian vertebrate ear generates replacement hair cells to restore hearing functions. Non-sensory support cells within the auditory epithelium play key roles in the repair processes.
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