Related Experiment Video
Updated: May 16, 2026

Laparoscopic Left Lateral Sectionectomy: Guided by the Ligamentum Teres Hepatis and the Umbilical Fissure Vein
Published on: September 27, 2024
Unprotected left main distal bifurcation lesion
George Karavolias1, Panagiotis Karyofillis, Panagiota Georgiadou
1Second Department of Interventional Cardiology, Onassis Cardiac Surgery Centre, Athens, Greece.
Insights
Drug-eluting stents offer a safe and feasible treatment option for unprotected left main coronary artery disease, especially in high-risk patients unsuitable for bypass surgery.
Area of Science:
- Cardiology
- Interventional Cardiology
Background:
- Left main coronary artery disease (LMCD) is a high-risk condition with significant mortality.
- Coronary artery bypass grafting (CABG) is the current gold-standard treatment for unprotected LMCD.
- Drug-eluting stents (DES) have reduced restenosis and repeat revascularization rates in coronary artery disease.
Observation:
- Percutaneous coronary intervention (PCI) using DES is emerging as an alternative for unprotected LMCD.
- This approach is considered for patients at high risk for CABG or those refusing surgery.
- Updated European Society of Cardiology guidelines support angioplasty for selected LMCD patients.
Findings:
- Successful DES implantation for an unprotected left main bifurcation lesion was demonstrated.
- The patient was an 85-year-old individual with high perioperative risk.
- This highlights the feasibility and safety of PCI in selected high-risk patients.
Implications:
- DES PCI presents a viable therapeutic option for unprotected LMCD in specific patient groups.
- It expands treatment possibilities for elderly or high-risk patients.
- This case supports the integration of PCI into treatment algorithms for complex coronary artery disease.
Abstract:
Left main coronary artery disease is a high-risk condition with significant mortality. Currently, bypass surgery is considered the gold-standard treatment for unprotected left main disease. The introduction of drugeluting stents for the treatment of coronary artery disease has proved to reduce the rates of restenosis and, consequently, the need for repeat revascularisation; therefore, recently, percutaneous coronary intervention in the unprotected left main using drug-eluting stents has been considered another therapeutic option for patients at high risk for bypass surgery, or for patients who simply refuse bypass surgery. Based on the updated guidelines on myocardial revascularisation of the European Society of Cardiology, treating left main lesions by angioplasty is feasible and safe in selected patients. In this case report we demonstrate the successful implantation of drug-eluting stents for the treatment of an unprotected left main bifurcation lesion in an 85-year-old patient with high perioperative risk.
Related Concept Videos
Cardiac Catheterization III: Left Heart Catheterization
Mitral Stenosis I: Introduction
Peripheral Artery Disease I: Introduction
