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Association between cerebral microbleeds and cognitive function: a systematic review

Chunyan Lei1, Sen Lin, Wendan Tao

  • 1Stroke Clinical Research Unit, Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.

Journal of Neurology, Neurosurgery, and Psychiatry
|November 27, 2012
PubMed
Abstract

Insights

Cerebral microbleeds (MBs) are not silent; they are linked to cognitive decline. Research indicates MBs significantly impact cognitive function and may induce decline.

Area of Science:

  • Neurology
  • Neuroimaging
  • Gerontology

Background:

  • Cerebral microbleeds (MBs), defined as brain microvascular lesions, were traditionally considered asymptomatic.
  • Emerging evidence suggests a correlation between MBs and cognitive function decline.

Purpose of the Study:

  • To systematically review existing literature and determine the association between cerebral microbleeds and cognitive function.

Main Methods:

  • A systematic literature search was conducted across major databases (Cochrane Library, MEDLINE, EMBASE, CNKI).
  • Reference lists of relevant studies and reviews were also examined.
  • Meta-analysis (qualitative and quantitative) was performed on eligible studies.

Main Results:

  • Seven studies were included in the review.
  • Meta-analysis indicated a significant association between MBs and cognitive impairment (OR 3.06, 95% CI 1.59-5.89).
  • MBs in specific brain regions (frontal, temporal, basal ganglia) may also contribute to cognitive dysfunction.

Conclusions:

  • Cerebral microbleeds are not clinically silent.
  • MBs may act as a causative factor in cognitive function decline.
Keywords:
Cognition

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