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Hyaluronic acid promotes chick embryo fibroblast and chondroblast expression
R Cortivo1, A De Galateo, I Castellani
1Institute of Histology and Embryology, University of Padua, Italy.
Cell Biology International Reports
|February 1, 1990
Abstract:
15-day-chick-embryo fibroblasts and chondroblasts were cultured in the presence of high and low molecular weight exogenous hyaluronic acid (HA). Growth range and incorporation of radiolabelled sulphate and proline were determined. HA reduced cell proliferation to about 75% of controls, while incorporation of radiolabelled sulphate and proline was higher in HA-treated cultures of both chondroblasts and fibroblasts. The effect was not due to the polyanionic or polymeric nature of the molecule and appeared to be highly specific for HA.