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[Treatment of high grade intracranial stenoses]

P Dietrich1, C Roth, A Simgen

  • 1Klinik für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum des Saarlandes, Homburg/Saar, Kirrberger Straße, Homburg/Saar, Deutschland.

Der Radiologe
|November 27, 2012
PubMed

Insights

Intracranial stenosis causes 10% of strokes. This study retrospectively analyzed endovascular treatment for high-grade intracranial stenosis, comparing it with aggressive medical management.

Area of Science:

  • Neurology
  • Neurosurgery
  • Vascular Medicine

Context:

  • Intracranial stenosis is a significant cause of stroke, accounting for approximately 10% of all cases.
  • Current treatment options include medical management, intracranial bypass surgery, and endovascular procedures like angioplasty and stenting.
  • Despite advances, patients with high-grade intracranial stenosis often face a poor prognosis, highlighting the need for effective therapies.

Purpose:

  • To retrospectively evaluate the effectiveness and feasibility of endovascular treatment (angioplasty and stenting) for symptomatic high-grade intracranial stenosis.
  • To compare the outcomes of endovascular therapy with aggressive medical treatment, as suggested by the SAMMPRIS trial.
  • To analyze patient data from the department of neuroradiology at Homburg University of Saarland.

Summary:

  • The study focuses on patients with symptomatic high-grade intracranial stenosis, a condition linked to a substantial stroke risk.
  • It examines intracranial angioplasty and stenting as endovascular treatment options, building upon previous research like the WASID trial.
  • Findings are contextualized within the broader debate on aggressive medical management versus endovascular intervention, particularly following the SAMMPRIS trial.

Impact:

  • Provides insights into the comparative effectiveness of endovascular treatment versus medical management for intracranial stenosis.
  • Contributes to the evidence base for managing patients with high-grade intracranial stenosis and reducing secondary stroke risk.
  • Informs clinical decision-making regarding treatment strategies for this challenging patient population.

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