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Updated: May 16, 2026

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
07:27

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Published on: April 29, 2010

Recombination-restarted replication makes inverted chromosome fusions at inverted repeats

Ken'Ichi Mizuno1, Izumi Miyabe, Stephanie A Schalbetter

  • 1Genome Damage and Stability Centre, University of Sussex, Brighton, East Sussex BN1 9RQ, UK.

Nature
|November 27, 2012
PubMed
Summary

Replication restart after DNA damage can cause chromosomal rearrangements. Restarted forks U-turn at inverted repeats, generating gross chromosomal rearrangements (GCRs) and copy-number variations (CNVs) implicated in cancer and genomic disorders.

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