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Updated: May 16, 2026

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Published on: July 16, 2008
Preference toward a polylysine enantiomer in inhibiting prions
Karen S Jackson1, Jihyun Yeom, Youngmi Han
1Division of Laboratory Animal Resources, University of Kentucky, Lexington, KY, USA.
Abstract:
Differential anti-prion activity of polylysine enantiomers was studied. Based on our recent discovery that poly-L-lysine (PLK) is a potent anti-prion agent, we investigated suppression of prions in cultured cells using poly-D-lysine (PDK). The results showed that PDK was more efficacious than PLK to inhibit prions. Protein misfolding cyclic amplification assay demonstrated improved efficacy of PDK in inhibiting plasminogen-mediated prion propagation, corresponding to the enantio-preference of PDK observed in cultured cells. Furthermore, our study demonstrated that polylysines formed a complex with plasminogen. These results propose to hypothesize a plausible mechanism that elicits prion inhibition by polylysine enantiomers.
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