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Updated: May 16, 2026

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
Published on: March 18, 2022
Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis
M Mahjoub1, F Berenbaum, X Houard
1UR4 Ageing, Stress and Inflammation, Université Pierre et Marie Curie, 7 quai Saint-Bernard, 75252, Paris Cedex 5, France.
Abstract:
Osteoarthritis is a whole joint disease characterised by the disappearance of the cartilage associated with subchondral bone sclerosis, formation of osteophytes and a mild inflammation of the synovial membrane. Although all these events have been independently studied, functional interactions between these different joint tissues should exist, especially between subchondral bone and cartilage. Moreover, recent studies show that cartilage and subchondral bone act as a single functional unit. This review highlights this novel concept.
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