Related Experiment Video
Updated: May 16, 2026

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
Published on: March 18, 2022
Subchondral bone and osteoarthritis: biological and cellular aspects
Y Henrotin1, L Pesesse, C Sanchez
1Bone and Cartilage Research Unit, University of Liège, 4000, Liège, Belgium. yhenrotin@ulg.ac.be
Abstract:
The subchondral bone is involved in the pathophysiology of osteoarthritis (OA), both by biochemical and mechanical pathways. Overloaded OA subchondral bone osteoblasts express a pro-angiogenic and pro-inflammatory phenotype which contributes to explain the structural changes (sclerosis and bone marrow lesion) visible in OA subchondral bone. Further, microfractures and conjonctivo-vascular structures constitute exchange routes between bone and the overlying cartilage for mediators produced by osteoblasts. This narrative review describes these physiopathological mechanisms and identifies possible therapeutic targets for pharmacological modalities.
Related Concept Videos
Growth of Cartilage and Bone Tissue
Osteoclasts in Bone Remodeling
Bone Formation by Endochondral Ossification
Bone Remodeling
