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Updated: May 16, 2026

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
Published on: May 6, 2020
MRI in OA: from cartilage to bone marrow lesion
D Loeuille1, I Chary-Valckenaere
1Service de Rhumatologie, CHU Nancy Brabois, rue du Morvan, 54500, Vandoeuvre-lès-Nancy, France. d.loeuille@chu-nancy.fr
Abstract:
In contrast to radiography, magnetic resonance imaging permits visualization of all articular structures affected by osteoarthritis. Many studies have demonstrated its potential to elucidate the pathophysiological phenomena that lead to joint destruction, quantify cartilage damage, and establish risk factors for chondrolysis. Bone marrow lesion is a well-recognized process localized just beneath the subchondral bone that is responsible for clinical symptoms and structural changes not only to bone but also to cartilage.
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