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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: May 16, 2026

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
11:02

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Published on: August 3, 2011

Reconstructing skin cancers using animal models.

Michael D Gober1, Hasan M Bashir, John T Seykora

  • 1Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Cancer Metastasis Reviews
|November 27, 2012
PubMed
Summary

Animal cancer models are crucial for understanding skin cancer development and creating new treatments. This review highlights key models for basal cell carcinoma, squamous cell carcinoma, and melanoma research.

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Area of Science:

  • Oncology
  • Dermatology
  • Translational Medicine

Background:

  • Skin cancer, including nonmelanoma and melanoma, is highly prevalent, with millions of cases diagnosed annually.
  • Understanding the molecular mechanisms of skin cancer is essential for developing effective treatments.
  • Animal models provide valuable platforms for studying cancer pathogenesis and therapeutic development.

Purpose of the Study:

  • To review significant animal models used in skin cancer research.
  • To highlight the utility of these models in identifying key molecular pathways in basal cell carcinoma, squamous cell carcinoma, and melanoma.
  • To underscore the role of animal models in advancing targeted anticancer therapeutics.

Main Methods:

  • Literature review of established and emerging animal models for skin cancer.
  • Analysis of studies utilizing these models to elucidate molecular pathways.
  • Synthesis of findings related to therapeutic target identification.

Main Results:

  • Identified key animal models crucial for basal cell carcinoma research.
  • Highlighted models instrumental in understanding squamous cell carcinoma pathogenesis.
  • Discussed models that have advanced melanoma research and therapeutic strategies.

Conclusions:

  • Animal models are indispensable tools for dissecting skin cancer biology.
  • These models facilitate the discovery of novel therapeutic targets and treatment strategies.
  • Continued development and application of animal models will accelerate progress in combating skin cancer.