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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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Related Experiment Video

Updated: May 16, 2026

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
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Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

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Single photon emission computed tomography tracer.

Cristina Müller1, Roger Schibli

  • 1Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen-PSI, Switzerland. cristina.mueller@psi.ch

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|November 27, 2012
PubMed
Summary

Developing new Single Photon Emission Computed Tomography (SPECT) tracers is crucial for advancing cancer detection and therapy monitoring. This research explores novel SPECT radiotracers, focusing on optimizing design for improved tumor targeting and imaging specificity.

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Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

Area of Science:

  • Nuclear Medicine
  • Radiopharmaceutical Chemistry
  • Oncology Imaging

Background:

  • Single Photon Emission Computed Tomography (SPECT) is a key nuclear medicine imaging technique.
  • Limited development of new SPECT tracers over the past two decades hinders its full potential in oncology.
  • Effective SPECT imaging for cancer requires radiotracers with specific tumor targeting, high uptake, and rapid clearance.

Purpose of the Study:

  • To review recent advancements in tumor-targeted SPECT radiotracers for cancer imaging.
  • To discuss strategies for optimizing SPECT tracer design.
  • To identify potential pitfalls and causes of failure in SPECT radiotracer development.

Main Methods:

  • Review of recent developments in SPECT radiotracer design for oncology.
  • Analysis of critical components: targeting biomolecules and radionuclides.
  • Discussion of rational design principles balancing target binding and clearance.

Main Results:

  • Recent progress has been made in developing novel SPECT radiotracers for various cancers.
  • Optimization strategies focus on enhancing affinity, specificity, and pharmacokinetic properties.
  • Design failures often stem from inadequate target engagement or unfavorable biodistribution.

Conclusions:

  • Advancements in SPECT radiotracer design are vital for improving cancer diagnosis, staging, and treatment response assessment.
  • A rational, component-evaluated approach is essential for successful SPECT tracer development.
  • Future research should focus on innovative designs to overcome current limitations and expand SPECT's clinical utility in oncology.