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Antineutrophil cytoplasmic autoantibody-associated vasculitis in Chinese patients
Peng-Cheng Xu1,2,3,4,5, Min Chen1,2,3,4, Ming-Hui Zhao6,7,8,9,10
1Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Abstract:
Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a common autoimmune disease in China. AAVs in the majority of Chinese patients are microscopic polyangiitis with antigenicity to myeloperoxidase. Propylthiouracil is the leading cause of drug-induced AAV. The genetic background and immunological characteristics of ANCA, such as the epitope, IgG subclass and avidity, might contribute to various clinical phenotypes of AAV.
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