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Transgenic Organisms00:53

Transgenic Organisms

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Transgenic Organisms00:53

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Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...

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Generation of Transgenic Rats using a Lentiviral Vector Approach
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Tet-Transgenic Rodents: a comprehensive, up-to date database.

Kai Schönig1, Sabine Freundlieb, Manfred Gossen

  • 1Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Mannheim, Germany.

Transgenic Research
|November 27, 2012
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Summary

The Tet-Transgenic Rodents database catalogs over 500 Tet-transgenic mouse lines and new rat models. This resource aims to streamline research by enabling the reuse of established, validated transgenic rodent models.

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Last Updated: May 16, 2026

Generation of Transgenic Rats using a Lentiviral Vector Approach
09:07

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Published on: May 17, 2020

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Area of Science:

  • Biotechnology
  • Genetics
  • Animal Models

Background:

  • Tet-transgenic technology is crucial for inducible gene expression in research.
  • Numerous Tet-transgenic mouse lines have been developed over the past two decades.
  • Tet-transgenic rat models are emerging as valuable research tools.

Purpose of the Study:

  • To create a comprehensive database of Tet-transgenic rodent lines.
  • To facilitate the reuse of validated transgenic lines.
  • To serve as a centralized resource for researchers in genetics and biotechnology.

Main Methods:

  • Compilation of published Tet-transgenic mouse and rat lines.
  • Database organization based on Tet technology components (Ptet promoter and transactivator).
  • Categorization of lines based on promoter-transactivator or Ptet-responder transgene configurations.

Main Results:

  • Documentation of over 500 Tet-transgenic mouse lines.
  • Inclusion of the first reported Tet-transgenic rat models.
  • Structured database with distinct sections for different transgenic configurations.

Conclusions:

  • The Tet-Transgenic Rodents database provides a valuable resource for the research community.
  • Facilitates efficient research by enabling the use of existing transgenic models.
  • Supports advancements in genetic engineering and the study of gene function in rodents.