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Related Concept Videos

Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency
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Published on: February 2, 2024

Cellular reprogramming and cancer development.

Katsunori Semi1, Yutaka Matsuda, Kotaro Ohnishi

  • 1Department of Reprogramming Science, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan.

International Journal of Cancer
|November 28, 2012
PubMed
Summary
This summary is machine-generated.

Reprogramming technology offers a novel approach to investigate the functional significance of epigenetic abnormalities in cancer development. This method can induce global epigenetic changes, aiding in cancer research and modeling.

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Area of Science:

  • Oncology
  • Epigenetics
  • Stem Cell Biology

Background:

  • Cancer arises from accumulated genetic and epigenetic changes.
  • The functional role of epigenetic alterations in cancer is not well understood due to limited modification tools.
  • Reverse genetic approaches have validated the role of genetic alterations in cancer.

Purpose of the Study:

  • To explore the potential of reprogramming technology in understanding epigenetic abnormalities in cancer.
  • To investigate the similarities between cellular reprogramming and carcinogenesis.
  • To discuss the application of induced pluripotent stem cell technology in cancer modeling.

Main Methods:

  • Discussing the dynamic epigenetic changes during reprogramming.
  • Comparing reprogramming processes with carcinogenesis.
  • Highlighting similarities between cancer cells and induced pluripotent stem cells.

Main Results:

  • Reprogramming technology can induce global epigenetic changes in cancer genomes.
  • This technology can serve as a tool to investigate the functional significance of epigenetic modifications in cancer.
  • Induced pluripotent stem cell technology can be applied to cancer modeling.

Conclusions:

  • Reprogramming technology provides a new avenue for studying epigenetic regulation in cancer.
  • The similarities between reprogramming and cancer suggest its utility in understanding cancer development and modeling.
  • Further research using reprogramming may illuminate the role of epigenetics in oncogenesis.