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Updated: May 16, 2026

Basics of Multivariate Analysis in Neuroimaging Data
Published on: July 24, 2010
Orthogonalized residuals for estimation of marginally specified association parameters in multivariate binary data
Bahjat F Qaqish1, Richard C Zink, John S Preisser
1Department of Biostatistics, University of North Carolina at Chapel Hill.
Abstract:
This paper focuses on marginal regression models for correlated binary responses when estimation of the association structure is of primary interest. A new estimating function approach based on orthogonalized residuals is proposed. A special case of the proposed procedure allows a new representation of the alternating logistic regressions method through marginal residuals. The connections between second-order generalized estimating equations, alternating logistic regressions, pseudo-likelihood and other methods are explored. Eficiency comparisons are presented, with emphasis on variable cluster size and on the role of higher-order assumptions. The new method is illustrated with an analysis of data on impaired pulmonary function.
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