Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hyperosmolar Hyperglycemic State

Hyperosmolar Hyperglycemic State

Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...

Renal Tubule and Collecting Duct

Renal Tubule and Collecting Duct

The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...

Diabetes Insipidus II: Pathophysiology

Diabetes Insipidus II: Pathophysiology

Normally, water balance is maintained through three interconnected mechanisms: the hypothalamic thirst center, the synthesis and release of antidiuretic hormone (ADH, or vasopressin), and the kidneys' responsiveness to this hormone. ADH is synthesized in the hypothalamus, released from the posterior pituitary, and acts on the distal nephron, allowing water reabsorption and concentrated urine production.Diabetes Insipidus and Its TypesIn diabetes insipidus (DI), this regulatory system is...

Diabetes Insipidus I: Introduction

Diabetes Insipidus I: Introduction

Definition Diabetes insipidus is a disorder marked by the production of large amounts of dilute urine because of impaired vasopressin production, release, or kidney response. The lack of effective vasopressin action limits water reabsorption in the renal collecting ducts, which leads to excessive urinary water loss and intense thirst.Clinical PresentationIndividuals with diabetes insipidus report persistent thirst and very high urine output. In severe cases, fluid intake can reach up to 20...

Desmosomes

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...

Disorder of Water Balance

Disorder of Water Balance

Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Low-Density Lipoprotein Cholesterol Goal Attainment in Indian Patients With Coronary Artery Disease: A Nationwide Study.

JACC. Asia·2026

Same author

Different Methods of Low-density Lipoprotein Cholesterol Estimation and the Impact on Lipid-lowering Therapy in Patients with Coronary Artery Disease.

The Journal of the Association of Physicians of India·2026

Same author

Sarcopenia and sarcopenic obesity in type 2 diabetes mellitus and cardiovascular disease: current perspective and narrative review.

Endocrine regulations·2025

Same author

Optimizing Cardiovascular Outcomes With Bisoprolol: An Evidence-Based Perspective.

Cureus·2025

Same author

Insights into the molecular mechanism of pulmonary vein stenosis in pediatric patients with congenital heart disease.

JTCVS open·2025

Same author

Prevalence of stage B heart failure in patients undergoing echocardiography during regular clinical practice.

Indian heart journal·2025

Search research articles

Related Experiment Video

Updated: May 16, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Hypohidrotic ectodermal dysplasia.

Manish Bansal¹, Kajal Manchanda, Shyam Sunder Pandey

¹Department of Dermatology and Venereology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

International Journal of Trichology

|November 28, 2012

Summary

This summary is machine-generated.

Hypohidrotic ectodermal dysplasia (ED) is an inherited disorder affecting ectodermal structures. This case study confirms the diagnosis in a 21-year-old female with characteristic symptoms like hypohidrosis and dental anomalies.

Keywords:

Ectodermal dysplasia hypodontia hypohidrotic

More Related Videos

Assessing Signaling Properties of Ectodermal Epithelia During Craniofacial Development

Assessing Signaling Properties of Ectodermal Epithelia During Craniofacial Development

Published on: March 24, 2011

Related Experiment Videos

Last Updated: May 16, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Assessing Signaling Properties of Ectodermal Epithelia During Craniofacial Development

Assessing Signaling Properties of Ectodermal Epithelia During Craniofacial Development

Published on: March 24, 2011

Area of Science:

Genetics and Developmental Biology
Dermatology
Oral Medicine

Background:

Ectodermal dysplasias (ED) encompass inherited conditions impacting ectodermal derivatives.
Classified into hypohidrotic and hidrotic forms, ED presents diverse clinical manifestations.
Understanding ED subtypes is crucial for accurate diagnosis and management.

Observation:

A 21-year-old female presented with hypohidrosis, reduced scalp/eyebrow hair, dry skin, and perioral/periorbital wrinkling.
Intraoral examination revealed hypodontia and characteristic peg-shaped teeth.
Routine investigations were unremarkable, but orthopantomogram showed multiple missing and peg-shaped teeth.

Findings:

Histopathological analysis revealed a thinned epidermis.
A significant reduction in eccrine gland units was observed.
These findings, combined with clinical presentation, confirmed Hypohidrotic ED.

Implications:

This case highlights the importance of recognizing clinical signs for diagnosing Hypohidrotic ED.
Early diagnosis facilitates genetic counseling and management of associated symptoms.
Further research into ED pathogenesis can lead to targeted therapeutic strategies.