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Updated: May 16, 2026

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
Published on: August 28, 2012
Jekyll and Hide: The two faces of amyloid β
1Hotchkiss Brain Institute; Department of Clinical Neuroscience; Calgary, AB Canada.
Abstract:
Neurodegenerative diseases are a burden of our century. Although significant efforts were made to find a cure or relief to this scourge, their pathophysiology remains vague and the cellular function of the key involved proteins is still unclear. However, in the case of amyloid β (Aβ), a key protein concerned in Alzheimer disease, we are now a step closer in the unscrambling of its cellular functions. Interestingly, whereas the exact role of Aβ in the pathophysiology of Alzheimer disease is still unresolved, a recent study revealed a neuroprotective function of Aβ in multiple sclerosis with possibly promising therapeutic benefits.
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