Related Experiment Video
Updated: May 16, 2026

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
Published on: February 17, 2018
A Rare Case of Very Early Pacemaker Twiddler's Syndrome
Saroj Mandal1, Arindam Pande, Dhiman Kahali
1Department of Cardiology, BM Birla Heart Research Institute, Kolkata, West Bengal, India.
Insights
Twiddler's syndrome, a rare pacemaker complication, can occur early due to lead dislodgement from patient manipulation. Active fixation of pacemaker leads is crucial for preventing this potentially lethal issue.
Area of Science:
- Cardiology
- Medical Devices
- Patient Safety
Background:
- Twiddler's syndrome is a rare complication of cardiac pacemakers.
- It typically involves lead dislodgement caused by patient manipulation.
- Diagnosis usually occurs within the first year post-implantation.
Observation:
- This report details a case of Twiddler's syndrome diagnosed within 48 hours of permanent pacemaker implantation.
- The patient's passive fixation of the ventricular lead contributed to the lead dislodgement.
- The syndrome was effectively managed by switching to active fixation of the device leads.
Findings:
- Early-onset Twiddler's syndrome can occur within hours of pacemaker implantation.
- Passive lead fixation may increase the risk of lead dislodgement in susceptible patients.
- Active fixation of pacemaker leads is a reliable method to prevent lead dislodgement.
Implications:
- This case highlights the importance of considering Twiddler's syndrome even in the immediate post-implantation period.
- Active fixation of pacemaker leads should be strongly considered to mitigate the risk of Twiddler's syndrome.
- Implementing active fixation strategies can improve patient safety and reduce pacemaker-related complications.
Abstract:
Twiddler's syndrome, a rare but potentially lethal complication of cardiac pacemaker treatment, is generally diagnosed within the first year of implantation. It is characterized by device malfunction due to dislodgement of cardiac leads resulting from some form of manipulation by the patient. In this report we present a patient who was diagnosed Twiddler's syndrome within the initial 48 h of implantation of permanent pacemaker. In our case, passive fixation of ventricular lead perpetuated this situation and subsequent active fixation prevented any recurrence. Active fixations fixations of device leads are very much essential to prevent this catastrophic complication.
Related Concept Videos
Dysrhythmias III: Characteristics of Dysrhythmias
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
Dysrhythmias II: Classification of Tachyarrhythmias
Dysrhythmias IV: Characteristics of Bradyarrhythmias
Dysrhythmias I: Introduction
Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...

