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Related Concept Videos

Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

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Related Experiment Video

Updated: May 16, 2026

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
02:49

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

Published on: February 23, 2024

Pediatric burn injuries.

Vijay Krishnamoorthy1, Ramesh Ramaiah, Sanjay M Bhananker

  • 1Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA.

International Journal of Critical Illness and Injury Science
|November 28, 2012
PubMed
Summary
This summary is machine-generated.

Pediatric burn care requires intensive medical and surgical therapy for multisystemic effects and pain management. Specialized burn centers with multidisciplinary teams offer optimal treatment for severe pediatric thermal injuries.

Keywords:
Burnspediatrictrauma

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Last Updated: May 16, 2026

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
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Published on: February 23, 2024

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
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Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Published on: November 6, 2018

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection
08:40

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection

Published on: August 23, 2022

Area of Science:

  • Pediatric medicine
  • Trauma surgery
  • Burn management

Background:

  • Pediatric burns are a significant global health issue, caused by scalds, fire, or abuse.
  • Burn severity is classified by body surface area and depth, impacting multiple organ systems.

Purpose of the Study:

  • To review the critical components of pediatric burn care.
  • To highlight pathophysiologic consequences, circulatory, respiratory, surgical, and pain management strategies.

Main Methods:

  • This is a review article, synthesizing current knowledge on pediatric burn management.
  • It emphasizes the multidisciplinary approach in specialized burn centers.

Main Results:

  • Large burn injuries lead to multisystemic manifestations requiring intensive support.
  • Effective management involves medical therapy for organ dysfunction and surgical intervention to prevent complications like sepsis.

Conclusions:

  • Comprehensive burn care is essential for critically ill pediatric patients.
  • Specialized burn centers provide the optimal environment for managing severe thermal injuries in children.