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Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

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Related Experiment Video

Updated: May 16, 2026

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration
06:21

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration

Published on: April 27, 2018

Progress in gene therapy for prostate cancer.

Kamran A Ahmed1, Brian J Davis, Torrence M Wilson

  • 1Department of Radiation Oncology, Mayo Clinic Rochester, MN, USA.

Frontiers in Oncology
|November 28, 2012
PubMed
Summary

Gene therapy using the sodium-iodide symporter (NIS) gene shows promise for treating prostate cancer. This approach facilitates radioactive iodine uptake, significantly delaying tumor growth and improving survival rates.

Keywords:
gene therapyprostate cancersodium-iodide symporter

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Area of Science:

  • Oncology
  • Gene Therapy
  • Molecular Biology

Background:

  • Prostate cancer is a leading cause of cancer death in American men.
  • Gene therapy offers potential for correcting disease processes, but efficient tumor transduction remains a challenge.
  • The sodium-iodide symporter (NIS) gene's ability to transport iodide presents a potential therapeutic avenue.

Purpose of the Study:

  • To evaluate the efficacy of NIS gene therapy for prostate cancer treatment.
  • To address the barrier of inefficient tumor transduction in cancer gene therapy.
  • To explore the potential of NIS as a therapeutic gene for malignancies.

Main Methods:

  • Adenovirus vectors were used to transfer the human NIS gene into prostate cancer cells in vitro and in vivo.
  • Radioactive iodine uptake was measured in transduced tumor cells.
  • Tumor growth delay and survival rates were assessed in preclinical models.

Main Results:

  • Successful transfer of the NIS gene into prostate cancer was achieved.
  • Transduced tumors demonstrated efficient uptake of radioactive iodine.
  • Significant tumor growth delay and prolonged survival were observed in preclinical studies.
  • A Phase I clinical trial for advanced prostate disease has been initiated.

Conclusions:

  • NIS gene therapy is a promising strategy for prostate cancer treatment.
  • The NIS gene facilitates targeted delivery of radioactive iodine for cancer therapy.
  • Further clinical studies are warranted to determine the full potential of NIS gene therapy for various cancers.