Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Immunologic risk stratification of pediatric heart transplant patients by combining HLA-EMMA and PIRCHE-II.

Frontiers in immunology·2023

Same author

Differential cytokine and chemokine expression during rejection and infection following intestinal transplantation.

Transplant immunology·2021

Same author

Molecular events contributing to successful pediatric cardiac transplantation in HLA sensitized recipients.

Human immunology·2019

Same author

Banff Lung Report: Current knowledge and future research perspectives for diagnosis and treatment of pulmonary antibody-mediated rejection (AMR).

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2018

Same author

Pediatric heart transplantation across a positive crossmatch: First year results from the CTOTC-04 multi-institutional study.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2018

Same author

Isolated vascular "v" lesions in liver allografts: How to approach this unusual finding.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2018

Search research articles

Related Experiment Video

Updated: May 16, 2026

Small Bowel Transplantation In Mice

Small Bowel Transplantation In Mice

Published on: August 20, 2007

Immunologic challenges in small bowel transplantation.

M Berger¹, A Zeevi, D G Farmer

¹Immunology R&D, CSL Behring, LLC, King of Prussia, PA, USA. mel.berger@cslbehring.com

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons

|November 28, 2012

Summary

This summary is machine-generated.

Small-bowel transplantation (SBT) success hinges on managing immune responses. Monitoring antidonor antibodies and utilizing therapies like complement inhibitors are key to improving long-term graft survival.

More Related Videos

Orthotopic Small Bowel Transplantation in Rats

Orthotopic Small Bowel Transplantation in Rats

Published on: November 6, 2012

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment

Published on: June 10, 2025

Related Experiment Videos

Last Updated: May 16, 2026

Small Bowel Transplantation In Mice

Small Bowel Transplantation In Mice

Published on: August 20, 2007

Orthotopic Small Bowel Transplantation in Rats

Orthotopic Small Bowel Transplantation in Rats

Published on: November 6, 2012

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment

Published on: June 10, 2025

Area of Science:

Transplantation immunology
Graft acceptance mechanisms
Immunosuppression strategies

Background:

Small-bowel and multivisceral transplantation have increased following tacrolimus introduction.
Graft immune activation occurs rapidly due to ischemia-reperfusion injury and luminal factors.
The role of the liver in promoting allograft acceptance requires further elucidation.

Framework:

Innate immune system activation in the graft necessitates control by regulatory cells.
Anti-donor antibodies, particularly anti-HLA, significantly impact long-term graft survival.
Development of de novo HLA antibodies or increased antibody function (e.g., C1q binding) elevates graft loss risk.

Implementation:

Monitoring antidonor antibody production is crucial for assessing graft status.
Investigating the mechanisms behind liver inclusion in allografts may reveal acceptance pathways.
Therapeutic strategies targeting immune responses are essential for successful transplantation.

Implications:

Improved monitoring of antidonor antibodies can predict graft outcomes.
Novel therapies, such as complement inhibitors, offer promise for enhancing graft survival.
Further research into immune regulation and antibody-mediated rejection is vital for advancing small-bowel transplantation.