Related Experiment Video
Updated: May 16, 2026

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
Published on: September 9, 2022
[Stress and auto-immunity]
I Delévaux1, A Chamoux, O Aumaître
1Service de médecine interne, CHU de Clermont-Ferrand, 58 rue Montalembert, Clermont-Ferrand cedex 1, France. idelevaux@chu-clermontferrand.fr
Abstract:
The etiology of auto-immune disorders is multifactorial. Stress is probably a participating factor. Indeed, a high proportion of patients with auto-immune diseases report uncommon stress before disease onset or disease flare. The biological consequences of stress are increasingly well understood. Glucocorticoids and catecholamines released by hypothalamic-pituitary-adrenal axis during stress will alter the balance Th1/Th2 and the balance Th17/Treg. Stress impairs cellular immunity, decreases immune tolerance and stimulates humoral immunity exposing individuals to autoimmune disease among others. The treatment for autoimmune disease should include stress management.
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