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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and lactation.

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Related Experiment Video

Updated: May 16, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Obesity and reproductive function.

Emily S Jungheim1, Jennifer L Travieso, Kenneth R Carson

  • 1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Washington University in St Louis, St Louis, MO 63108, USA. jungheime@wustl.edu

Obstetrics and Gynecology Clinics of North America
|November 28, 2012
PubMed
Summary
This summary is machine-generated.

Obesity negatively impacts reproductive health through complex, poorly understood mechanisms. This review explores these links and discusses public health policies for treating infertility in obese women.

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Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
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Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

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Last Updated: May 16, 2026

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White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice
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Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
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Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

Area of Science:

  • Reproductive Endocrinology
  • Metabolic Syndrome Research
  • Public Health Policy

Background:

  • Obesity is linked to numerous adverse reproductive outcomes.
  • The precise biological mechanisms connecting obesity and reproductive dysfunction remain largely unidentified.
  • Both obesity and human reproduction are recognized as complex systems with nonlinear interactions.

Purpose of the Study:

  • To review the adverse reproductive outcomes associated with obesity.
  • To elucidate the underlying mechanisms linking obesity to reproductive issues.
  • To discuss public health policy for managing infertility in obese women.

Main Methods:

  • Literature review of studies on obesity and reproductive health.
  • Analysis of complex systems theory applied to reproductive endocrinology.
  • Synthesis of current research on obesity-related infertility.

Main Results:

  • Obesity contributes to a range of reproductive problems.
  • Identifying specific causal pathways is challenging due to the complex, multifactorial nature of obesity and reproduction.
  • Existing research highlights the need for integrated approaches to treatment.

Conclusions:

  • Understanding the complex interplay between obesity and reproduction is crucial.
  • Effective public health strategies are needed to address infertility in obese populations.
  • Further research into the nonlinear mechanisms is warranted.