Related Experiment Video
Updated: May 16, 2026

A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English
Published on: April 3, 2026
A4S: a user-friendly graphical tool for pharmacokinetic and pharmacodynamic (PK/PD) simulation
Massimiliano Germani1, Francesca Del Bene, Maurizio Rocchetti
1Pharmacokinetics and Modeling, Accelera S.r.l., Viale Pasteur 10, 20014 Nerviano (MI), Italy. massimiliano.germani@accelera.org
Abstract:
Effective communication of PK/PD principles and results in a biomedical research environment remains a significant challenge which can result in lack of buy-in and engagement from scientists outside the modeling and simulation communities. In our view, one of the barriers in this area is a lack of user-friendly tools which allow "non experts" to use PK/PD models without the need to develop technical skills and expertise in advanced mathematical principles and specialist software. The costs of commercial software may also prevent large-scale distribution. One attempt to address this issue internally in our research organizations has resulted in the development of the A4S ("Accelera for Sandwich") software, which is a simple-to-use, menu-drive Matlab-based PK/PD simulator targeted at biomedical researchers with little PK/PD experience.
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