Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A novel bis-aryl urea compound inhibits tumor proliferation via cathepsin D-associated apoptosis.

Anti-cancer drugs·2020

Same author

Detection of <i>Chlamydia psittaci</i> and <i>Chlamydia ibidis</i> in the Endangered Crested Ibis (<i>Nipponia nippon</i>).

Epidemiology and infection·2020

Same author

Astragaloside IV protects ATDC5 cells from lipopolysaccharide-caused damage through regulating miR-203/MyD88.

Pharmaceutical biology·2020

Same author

Depletion of CDC5L inhibits bladder cancer tumorigenesis.

Journal of Cancer·2020

Same author

Evaluation of Survival Outcomes With Trimodal Therapy as Primary Therapy for Non-organ-confined Bladder Cancer.

Frontiers in oncology·2019

Same author

Transcription factor NFAT5 contributes to the glycolytic phenotype rewiring and pancreatic cancer progression via transcription of PGK1.

Cell death & disease·2019

Search research articles

Related Experiment Video

Updated: May 16, 2026

A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways

A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways

Published on: May 9, 2016

Modeling the dynamic flow-fiber interaction for microscopic biofluid systems.

Xuewen Yin¹, Junfeng Zhang

¹Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada ON M5S 3G8.

Journal of Biomechanics

|November 28, 2012

Summary

This summary is machine-generated.

This study presents a 3D numerical model for microscopic flow-fiber interactions in biofluids. Simulations reveal fibers oscillate periodically in sinusoidal shear flow, offering insights into dynamic biofluid systems.

More Related Videos

Development of a Microfluidics-Based Approach for Investigating Microtubule Polymer Mechanics

Development of a Microfluidics-Based Approach for Investigating Microtubule Polymer Mechanics

Published on: May 30, 2025

Combining Fluidic Devices with Microscopy and Flow Cytometry to Study Microbial Transport in Porous Media Across Spatial Scales

Combining Fluidic Devices with Microscopy and Flow Cytometry to Study Microbial Transport in Porous Media Across Spatial Scales

Published on: November 25, 2020

Related Experiment Videos

Last Updated: May 16, 2026

A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways

A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways

Published on: May 9, 2016

Development of a Microfluidics-Based Approach for Investigating Microtubule Polymer Mechanics

Development of a Microfluidics-Based Approach for Investigating Microtubule Polymer Mechanics

Published on: May 30, 2025

Combining Fluidic Devices with Microscopy and Flow Cytometry to Study Microbial Transport in Porous Media Across Spatial Scales

Combining Fluidic Devices with Microscopy and Flow Cytometry to Study Microbial Transport in Porous Media Across Spatial Scales

Published on: November 25, 2020

Area of Science:

Multiphysics simulation
Computational fluid dynamics
Biofluid mechanics

Background:

Microscopic flow-fiber interactions are crucial in biological fluid dynamics.
Existing models may not fully capture the complex interplay between elastic fibers and fluid flow at micro-scales.

Purpose of the Study:

To develop and validate a novel three-dimensional numerical model for microscale flow-fiber interactions.
To investigate fiber deformation dynamics under different shear flow conditions.

Main Methods:

Employed a spring network model for elastic fiber representation.
Utilized the lattice Boltzmann method for simulating fluid flow.
Integrated the immersed boundary method for modeling flow-structure interaction.

Main Results:

The model successfully simulated fiber deformation under constant and sinusoidal shear flows.
Fibers reached equilibrium under constant shear.
Periodic oscillations in fiber shape, synchronized with the sinusoidal shear frequency, were observed, along with a continuous phase shift along the fiber.

Conclusions:

The developed 3D numerical model is effective for studying microscopic biofluid systems involving flow-fiber dynamics.
The findings highlight distinct fiber behaviors under different shear conditions, crucial for understanding biological processes.
Further research is warranted to explore interactions in diverse flow scenarios.