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Published on: July 8, 2016
A novel electrostatic dry coating process for enteric coating of tablets with Eudragit® L 100-55
Mingxi Qiao1, Liqiang Zhang2, Yingliang Ma2
1Department of Chemical and Biochemical Engineering, University of Western Ontario, Ontario, Canada; Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.
Summary
An electrostatic dry coating method using PEG400 as a plasticizer enhanced tablet enteric coating. This process improved powder adhesion and film formation for better acid resistance.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Enteric coating protects drugs from stomach acid and targets release in the intestine.
- Traditional coating methods face challenges with efficiency and uniformity.
Purpose of the Study:
- To develop and evaluate an electrostatic dry coating process for enteric coating of tablets using Eudragit® L 100-55.
- To compare the efficacy of PEG400 and triethyl citrate (TEC) as plasticizers in this process.
Main Methods:
- Utilized a liquid pan coater adapted for electrostatic dry coating.
- Investigated Eudragit® L 100-55 with PEG400 and TEC plasticizers.
- Employed Differential Scanning Calorimetry (DSC) to assess plasticizer efficiency.
- Analyzed powder adhesion, coating level, and efficiency with and without electrical charging (0 kV vs. 60 kV).
- Evaluated film formation and acid resistance using scanning electron microscopy and in vitro drug release tests after varying curing conditions.
Main Results:
- PEG400 demonstrated superior plasticizing effect on Eudragit® L 100-55 compared to TEC, evidenced by a greater reduction in glass transition temperature (Tg).
- PEG400 facilitated better powder adhesion due to higher surface presence and lower absorption into tablet cores.
- Electrostatically assisted coating (60 kV) significantly improved coating level and efficiency over non-charged coating (0 kV).
- Optimized curing conditions (higher temperature, longer time) enhanced film integrity and in vitro acid resistance.
Conclusions:
- The electrostatic dry coating process is effective for enteric coating of tablets.
- PEG400 is a more suitable plasticizer than TEC for this application, promoting better adhesion and coating.
- The process offers enhanced powder adhesion, coating efficiency, and improved film properties for acid resistance.
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