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[Modulation of hCG synthesis by alpha tumor necrosis factor in JAR choriocarcinoma cells]
C Marth1, S Madersbacher, M Herold
1Universitätsklinik für Frauenheilkunde, Osterreichischen Akademie der Wissenschaften, Innsbruck.
Geburtshilfe Und Frauenheilkunde
|February 1, 1990
Abstract:
The tumour necrosis factor (TNF) stimulates in cultured JAR choriocarcinoma cells the biosynthesis of hCG, including the free alpha and beta chain and the holo-hCG. Although elevated serum TNF levels have been shown by Balkwill et al. (1987) in about 50% of tumour patients, we were unable to confirm these data in the 10 examined patients, who had a choriocarcinoma. Despite its excellent in-vitro action, INF could not be confirmed to exercise an influence on the regulation of hCG in choriocarcinoma patients.