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A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

NutriChip: nutrition analysis meets microfluidics.

Qasem Ramadan¹, Hamideh Jafarpoorchekab, Chaobo Huang

¹Laboratory of Microsystems 2, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. qasem.alramadan@epfl.ch

|November 28, 2012

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NutriChip, a microfluidic platform, assesses dairy foods' immune effects using an artificial gut. This technology monitors immune cell biomarkers to evaluate food

Area of Science:

* Biotechnology and Food Science
* Immunology and Nutritional Science

Background:

* Investigating the immuno-modulatory effects of dairy products is crucial for understanding their health impacts.
* Existing methods for studying nutrient passage and immune response are limited in mimicking the human gastrointestinal tract (GIT).

Purpose of the Study:

* To introduce and validate the NutriChip, a microfluidic platform designed to assess the immuno-modulatory functions of dairy foods.
* To develop an in vitro model that accurately simulates the human GIT for nutrient-immune interaction studies.
* To screen dairy products for anti-inflammatory properties.

Main Methods:

* Development of a microfluidic device featuring an artificial human GIT with co-cultured epithelial and immune cells.
* Monitoring immune cell responses to pro-inflammatory stimuli (e.g., lipopolysaccharide) and dairy products.

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Last Updated: May 16, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

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* Quantification of pro-inflammatory cytokines (interleukin-1, interleukin-6) using an optical imager.

Main Results:

* The NutriChip successfully mimics the human GIT environment for studying nutrient-immune interactions.
* The platform can differentiate immune responses to various stimuli and dairy products.
* Expression levels of key immune cell biomarkers are quantifiable.

Conclusions:

* NutriChip offers a novel in vitro approach to evaluate the health influence of food quality.
* The platform enables the screening of dairy products for beneficial anti-inflammatory properties.
* Validated by human trials, NutriChip can advance personalized nutrition and food development.