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Intraocular pressure in very low birth weight preterm infants and its association with postconceptional age

Rodrigo L Lindenmeyer1, Lucas Farias, Taís Mendonça

  • 1Medical School, Federal University of Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Department of Ophthalmology, Porto Alegre/RS, Brazil.

Clinics (Sao Paulo, Brazil)
|November 28, 2012
PubMed

Insights

Intraocular pressure in very low birth weight preterm infants was measured weekly. Mean intraocular pressure decreased by 0.29 mmHg per week as postconceptional age advanced.

Area of Science:

  • Ophthalmology
  • Neonatology
  • Pediatrics

Background:

  • Intraocular pressure (IOP) regulation in preterm infants is not well understood.
  • Very low birth weight (VLBW) infants (<1,500 g) are at risk for various ophthalmic complications.

Purpose of the Study:

  • To evaluate intraocular pressure (IOP) in very low birth weight preterm infants.
  • To correlate IOP with postconceptional age in this vulnerable population.

Main Methods:

  • Prospective cohort study of VLBW infants (birth weight ≤1,500 g, gestational age ≤32 weeks).
  • Weekly IOP measurements were taken.
  • Mixed-effects models were used to analyze IOP variation with postconceptional age.

Main Results:

  • Fifty VLBW infants (mean gestational age 29.7 ± 1.6 weeks) were evaluated.
  • Mean IOP was 14.9 ± 4.5 mmHg.
  • IOP decreased by a mean of 0.29 mmHg per week of increasing postconceptional age (p=0.047).

Conclusions:

  • The mean intraocular pressure in VLBW preterm infants is 14.9 ± 4.5 mmHg.
  • A statistically significant inverse relationship exists between IOP and postconceptional age in VLBW infants.
Abstract

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