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Published on: November 9, 2016
Clinical pharmacy interventions in paediatric electronic prescriptions
Barbara Maat1, Yuen San Au, Casper W Bollen
1Department of Clinical Pharmacy, University Medical Center Utrecht, PO Box 85500, Utrecht 3508 GA, The Netherlands. B.Maat@umcutrecht.nl
Insights
Clinical pharmacy interventions are crucial for paediatric electronic prescriptions, with most correcting potential adverse events. Optimizing electronic prescribing systems, especially reducing free-text entries, can enhance patient safety and medication accuracy.
Area of Science:
- Clinical Pharmacy
- Paediatric Healthcare
- Health Informatics
Background:
- Electronic prescribing systems aim to improve medication safety but may not fully prevent errors.
- Clinical pharmacy interventions play a vital role in identifying and rectifying prescription errors in paediatric patients.
- Understanding the frequency and determinants of these interventions is essential for optimizing paediatric medication management.
Purpose of the Study:
- To determine the frequency and nature of clinical pharmacy interventions in paediatric electronic prescriptions.
- To identify factors influencing the need for interventions in paediatric electronic prescribing.
- To provide evidence-based recommendations for improving paediatric electronic prescribing systems.
Main Methods:
- A prospective cohort study with a nested case-control design was conducted.
- Data were collected from paediatric electronic prescriptions at a tertiary children's hospital.
- Prescriptions requiring intervention (cases) were compared with those not requiring intervention (controls).
Main Results:
- Interventions were made for 1.1% of paediatric electronic prescriptions, predominantly to correct potential adverse events.
- Wrong doses constituted the most common reason for intervention (45%).
- Higher risks of intervention were observed for younger children (1-2 years), free-text prescriptions, and oral dosage forms.
Conclusions:
- Paediatric prescribing errors are frequent despite electronic systems, highlighting the need for enhanced safety measures.
- Minimizing free-text entries and incorporating features like dose checking can improve electronic prescribing quality.
- This study offers insights for refining electronic prescribing to enhance safety and efficiency in paediatric care.
Objective:
To examine the frequency, nature and determinants of clinical pharmacy interventions in paediatric electronic prescriptions.
Design:
Prospective cohort with nested case-control study.
Setting:
Tertiary children's hospital, The Netherlands.
Patients:
Patients 0-18 years with at least one drug prescription admitted to hospital between 1 March 2004 and 1 January 2008, excluding patients receiving intensive care.
Interventions:
Electronic medication prescriptions for paediatric inpatients were verified and if necessary interventions were made by the paediatric clinical pharmacy. Prescriptions requiring intervention (cases) were compared with prescriptions not requiring interventions (controls).
Main Outcome Measures:
Frequency of clinical pharmacy interventions, per 10 000 paediatric electronic prescriptions, and the determinants thereof.
Results:
Interventions were made for 1577 (1.1%) of 138 449 prescriptions. 81% of the interventions concerned correction of a prescription that might have had adverse clinical consequences. Interventions in prescriptions for antibacterial agents for systemic use were made most often. Most corrections concerned wrong doses (45%). 1577 cases were compared with 1983 controls. The risk of interventions was higher for children aged 1 month to 2 years than for 12-18-year-olds (OR=1.97 (95% CI 1.63 to 2.38)). The risk for 'free-text' prescriptions was five times higher than for 'standardised structured template' prescriptions. No differences were found between day, evening and night shift prescriptions. Significantly more interventions were made in the oral dosage form (OR=1.63 (95% CI 1.41 to 1.88)) and administration route (OR=1.80 (95% CI 1.55 to 2.09)) than for other reasons.
Conclusions:
Paediatric prescribing errors occur frequently and are not completely prevented by electronic prescribing systems. This study provides information for improvements in electronic prescribing for paediatric patients. Incorporating tailored solutions, such as minimised free-text entry, certain obligatory fields and integrated dose checking and indications, can improve the quality and efficiency of electronic prescribing in paediatrics.
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