Soft-tissue and meningeal hemangiopericytomas: an immunohistochemical and ultrastructural study

The debate on the nosologic position of hemangiopericytomas of the meninges has been based mainly on light microscopic and ultrastructural considerations; recent immunohistochemical studies have yielded controversial results. We have used a panel of antibodies to vimentin, desmin, actin, S100 protein, epithelial membrane antigen, cytokeratins, Leu-7, factor VIII-related antigen and type IV collagen to compare the immunophenotype of 10 soft-tissue and seven meningeal hemangiopericytomas. The immunophenotypic profile of these tumors is identical, and differs from that of meningiomas in that epithelial membrane antigen and cytokeratin are not present. The vascular pattern occurring in some meningiomas can simulate true hemangiopericytomas of the meninges. Immunohistochemical studies should allow their distinction in each instance. Meningeal and soft-tissue hemangiopericytomas display similar ultrastructural features.