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Glycated proteome: from reaction to intervention.
Mahesh J Kulkarni1, Arvind M Korwar, Sheon Mary
1Proteomics Facility, Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune, India. mj.kulkarni@ncl.res.in
Proteomics. Clinical Applications
|November 28, 2012
Summary
Protein glycation, a sugar-protein reaction common in diabetes, affects key tissues and contributes to diseases like cancer and aging. This review covers glycation
Area of Science:
- Biochemistry and Molecular Biology
- Endocrinology and Metabolism
- Pathophysiology
Background:
- Glycation is a nonenzymatic reaction between reducing sugars and proteins.
- This process, known as protein glycation, occurs throughout the proteome.
- Hyperglycemia in diabetes significantly accelerates protein glycation.
Purpose of the Study:
- To review strategies for characterizing protein glycation.
- To discuss the functional implications of protein glycation in various diseases.
- To explore intervention strategies against detrimental glycation effects.
Main Methods:
- Literature review of studies on protein glycation characterization.
- Analysis of research on the role of glycation in disease pathogenesis.
- Synthesis of information on therapeutic interventions for protein glycation.
Main Results:
- Glycated proteins in plasma, kidney, lens, and brain are linked to disease.
- Protein glycation is implicated in diabetic complications, neurodegeneration, cancer, and aging.
- Various methods exist to identify and quantify glycated proteins.
Conclusions:
- Understanding protein glycation is crucial for disease management.
- Targeting glycation pathways offers potential therapeutic benefits.
- Further research is needed to develop effective interventions against protein glycation.
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