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Updated: May 16, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Transulnar sheathless percutaneous coronary intervention during bivalirudin infusion in high-risk elderly female with
Francesco Summaria1, Valerio Lucci, Marina Mustilli
1Interventional Cardiology, Policlinico Casilino;
Insights
Elderly patients with acute coronary syndromes (ACS) face high bleeding risks during percutaneous coronary intervention (PCI). This case study explores a sheathless PCI approach using bivalirudin in an 83-year-old woman with high bleeding risk.
Area of Science:
- Cardiology
- Interventional Cardiology
- Geriatric Medicine
Background:
- Increasingly, elderly patients with acute coronary syndromes (ACS) undergo percutaneous coronary intervention (PCI).
- Bleeding complications are common in ACS patients, significantly impacting prognosis and healthcare costs.
- Periprocedural bleeding, especially in older adults, is linked to adverse clinical outcomes and increased mortality.
Observation:
- An 83-year-old female presented with non-ST segment elevation myocardial infarction.
- The patient had a high bleeding risk and an unsuitable radial artery for standard PCI.
- She underwent a sheathless PCI procedure utilizing bivalirudin infusion.
Findings:
- The sheathless PCI technique was successfully employed in a high-risk elderly patient.
- Bivalirudin infusion was used as the anticoagulant during the procedure.
- The case highlights the feasibility of alternative PCI approaches in complex patient profiles.
Implications:
- This case demonstrates a potentially safer PCI strategy for elderly patients with elevated bleeding risks.
- Sheathless PCI may reduce vascular complications and bleeding events in this vulnerable population.
- Further research into sheathless techniques and anticoagulation strategies like bivalirudin is warranted for optimizing ACS management in the elderly.
Abstract:
Due to the ageing population and raised life expectancy, elderly patients are increasingly referred for percutaneous coronary intervention (PCI) during acute coronary syndromes (ACS). Bleeding complications are not infrequent during ACS, occurring in 2-5% of patients with prognostic and economic consequences. In particular, periprocedural bleeding and vascular complications are associated with worse clinical outcome, prolonged hospital stay and increased short- and long-term mortality, especially in elderly patients with acute coronary syndromes. We report the case of an 83-year old female referred to our hospital because of non-ST segment elevation myocardial infarction with high bleeding risk and unsuitable radial artery undergoing tran-sulnar sheathless PCI during bivalirudin infusion. The clinical, technical, pharmacological and prognostic implications are discussed.
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