Related Experiment Video
Updated: May 16, 2026

10:18
Concurrent Quantification of Cellular and Extracellular Components of Biofilms
Published on: December 10, 2013
Do antibacterial mouthrinses affect bacteraemia in third molar surgery? A pilot study
A Tuna1, C Delilbasi, A Arslan
1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Yeditepe University, Istanbul, Turkey.
Australian Dental Journal
|November 29, 2012
Summary
Antibacterial mouthrinses, including povidone iodine and chlorhexidine, may reduce bacteraemia after third molar surgery. Further research with larger populations is recommended to confirm these findings.
Area of Science:
- Oral Surgery
- Microbiology
- Pharmacology
Background:
- Impacted third molar surgery can lead to bacteraemia.
- Evaluating the efficacy of antiseptic mouthrinses is crucial for infection control.
Purpose of the Study:
- To assess the impact of 7.5% povidone iodine and 0.2% chlorhexidine mouthrinses on post-surgical bacteraemia.
- To compare these effects against a sterile saline control group.
Main Methods:
- A pilot study involving 34 patients undergoing impacted third molar surgery.
- Patients pre-rinsed with povidone iodine, chlorhexidine, or sterile saline.
- Blood samples were collected preoperatively and at 1 and 15 minutes post-surgery for microbiological analysis.
Main Results:
- Bacteraemia occurred in 33% of patients using povidone iodine, 33% using chlorhexidine, and 50% in the control group.
- Predominant isolates included anaerobes (58%) and Streptococcus species (92%).
- A reduction in bacteraemia incidence was observed with both antiseptic mouthrinses, though not statistically significant (p > 0.05).
Conclusions:
- Antibacterial mouthrinses show potential in reducing bacteraemia following third molar surgery.
- Larger-scale studies are needed to validate these preliminary findings and explore other agents.
Related Concept Videos
Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Tonsillitis II: Management
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
Bacterial Signaling
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Mechanism of Antibiotic Resistance in MRSA
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...