Inflammatory response attenuation in patients undergoing gasless laparoscopic gastrectomy

Area of Science:

• Surgical Oncology
• Minimally Invasive Surgery
• Immunology

Background:

• The clinical benefits of gasless laparoscopy versus conventional surgery remain debated.
• Systemic inflammatory markers and adhesion molecules are key indicators of surgical stress.

Purpose of the Study:

• To compare the systemic inflammatory response and adhesion molecule levels between gasless laparoscopy and open surgery.
• To evaluate the impact of surgical approach on postoperative recovery.

Main Methods:

• A comparative study involving 23 patients in the gasless laparoscopy (GL) group and 12 in the open surgery (OS) group.
• Serum levels of proinflammatory markers (IL-6, IL-8) and adhesion molecules (ICAM) were measured.
• Postoperative recovery parameters including pain scores, flatus, and hospital stay were assessed.

Main Results:

• Gasless laparoscopy resulted in a significantly smaller wound length (5.3±0.3cm vs. 8.9±0.5cm).
• Patients in the GL group experienced reduced postoperative pain, earlier flatus, and shorter hospital stays.
• Serum levels of IL-6, IL-8, and ICAM were significantly lower in the GL group.

Conclusions:

• Gasless laparoscopy-assisted gastrectomy (GLAG) elicits a less pronounced immune response compared to traditional open surgery.
• The reduced inflammatory response in GLAG may contribute to improved postoperative recovery outcomes.