Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 16, 2026

A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering
09:53

A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering

Published on: January 1, 2018

Hydrogel limits stem cell dispersal in the deaf cochlea: implications for cochlear implants.

Bryony A Nayagam1, Steven S Backhouse, Cengiz Cimenkaya

  • 1Department of Otolaryngology, University of Melbourne, Australia. b.nayagam@unimelb.edu.au

Journal of Neural Engineering
|November 29, 2012
PubMed
Summary

Stem cells (SCs) differentiated into neurons can be delivered to the deaf cochlea using a peptide hydrogel. This method successfully retained the cells and preserved existing auditory neurons, showing promise for cochlear implant therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cochlear Homeostasis in Sensorineural Hearing Loss: Mechanisms, Implications, and Therapeutic Prospects.

International journal of molecular sciences·2026
Same author

Trophic and temporal dynamics of macrophage biology in human inner ear organogenesis.

Frontiers in immunology·2025
Same author

Overcoming failure: improving acceptance and success of implanted neural interfaces.

Bioelectronic medicine·2025
Same author

Corrigendum: Organotypic culture of neonatal murine inner ear explants.

Frontiers in cellular neuroscience·2024
Same author

The mitral to aortic/pulmonary velocity-time integral ratio is a simple, feasible and accurate discriminator for echocardiographic evaluation of severe isolated mitral regurgitation.

The international journal of cardiovascular imaging·2024
Same author

Towards stem cell therapies for hearing loss: awareness and perspectives of Australian audiologists and their patients.

Regenerative medicine·2024

Area of Science:

  • Neuroscience
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Auditory neurons are crucial for cochlear implant function in deaf individuals.
  • Significant depletion of auditory neurons can hinder cochlear implant efficacy.
  • Stem cells (SCs) offer potential for replacing lost auditory neurons.

Purpose of the Study:

  • To investigate the targeted delivery and retention of stem cell-derived neurons in the deaf cochlea.
  • To evaluate the safety and efficacy of using a peptide hydrogel for cell transplantation.
  • To assess the impact of the procedure on endogenous auditory neurons.

Main Methods:

  • Transplantation of stem cell-derived neurons into the cochlea.
  • Utilized a peptide hydrogel to control cell dispersal and retention.

More Related Videos

Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice
09:34

Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice

Published on: May 25, 2018

In vitro Time-lapse Live-Cell Imaging to Explore Cell Migration toward the Organ of Corti
08:08

In vitro Time-lapse Live-Cell Imaging to Explore Cell Migration toward the Organ of Corti

Published on: December 4, 2020

Related Experiment Videos

Last Updated: May 16, 2026

A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering
09:53

A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering

Published on: January 1, 2018

Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice
09:34

Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice

Published on: May 25, 2018

In vitro Time-lapse Live-Cell Imaging to Explore Cell Migration toward the Organ of Corti
08:08

In vitro Time-lapse Live-Cell Imaging to Explore Cell Migration toward the Organ of Corti

Published on: December 4, 2020

  • Assessed cell survival, retention at the delivery site, and impact on endogenous neurons.

    • Main Results:

    • Stem cell-derived neurons were successfully delivered and retained in the basal turn of the cochlea.
    • The peptide hydrogel effectively limited cell dispersal.
    • No significant loss of endogenous auditory neurons was observed post-transplantation.
    • The surgical approach elicited a localized tissue response, confined to the cochlear basal turn.

    Conclusions:

    • Targeted delivery of stem cell-derived neurons using hydrogels is feasible in the mammalian cochlea.
    • This approach shows potential for future cell-based transplantation strategies to restore hearing.
    • Combined with cochlear implants, this method could improve functional outcomes for deaf individuals.