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Related Concept Videos

Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Glycocalyx and its Functions01:14

Glycocalyx and its Functions

The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
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The MUB40 Peptide for Use in Detecting Neutrophil-Mediated Inflammation Events
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Published on: January 7, 2019

Characterization and function of human Ly-6/uPAR molecules.

Hyun Kyung Kong1, Jong Hoon Park

  • 1Department of Biological Science, Sookmyung Women's University, Seoul, Korea.

BMB Reports
|November 29, 2012
PubMed
Summary

Human Ly-6/uPAR molecules, involved in immune system development and cancer, show promise as diagnostic and therapeutic targets. Their structure and function in normal and malignant tissues highlight their potential in cancer immunotherapy.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Immunology

Background:

  • Human Ly-6/uPAR molecules comprise membrane-bound and secreted subfamilies.
  • They share a conserved cysteine-rich domain and are encoded by genes on chromosome 8q23.
  • These molecules exhibit distinct expression patterns during hematopoiesis and in tumors.

Purpose of the Study:

  • To review the molecular structure and function of human Ly-6/uPAR molecules.
  • To explore their roles in normal and malignant tissues.
  • To evaluate their potential as targets for cancer immunotherapy.

Main Methods:

  • Literature review of studies on human Ly-6/uPAR molecules.
  • Analysis of molecular structure, including cysteine-rich domains and glycosylation.
  • Examination of expression patterns in hematopoiesis and cancer.

Main Results:

  • Ly-6/uPAR molecules possess conserved structural features and genomic organization.
  • Their expression is linked to immune system development and carcinogenesis.
  • They demonstrate utility as antigens for diagnostic and therapeutic applications.

Conclusions:

  • Human Ly-6/uPAR molecules are significant in immunity and cancer.
  • Their unique characteristics position them as valuable targets for cancer immunotherapy.
  • Further research into Ly-6/uPAR molecules can advance cancer diagnostics and therapeutics.