Related Experiment Video
Updated: May 16, 2026
10:01
The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
Published on: September 27, 2016
Detection of single-nucleotide polymorphisms based on the formation of an electron-transfer impeding layer on an
Zhiqiang Gao1, Wei Shen, Huimin Deng
1Department of Chemistry, National University of Singapore, 117543, Singapore. chmgaoz@nus.edu.sg
Chemical Communications (Cambridge, England)
|November 29, 2012
Abstract:
An electrochemical biosensor utilizing the electron-transfer impeding (insulating) power of a conducting polymer for label-free genotyping single-nucleotide polymorphisms is proposed. Excellent selectivity and sensitivity are accomplished through the engagement of a nuclease clean-up step and a cumulative signal generation/amplification process, respectively.
Related Concept Videos
01:20Capillary Electrophoresis: Instrumentation
Capillary electrophoresis instrumentation typically consists of several key components. A high-voltage power supply generates the electric field necessary for the separation by connecting to an anode (the positively charged electrode) and a cathode (the negatively charged electrode) located in buffer reservoirs at each end of the capillary tube. The system includes a sample vial, a fused silica capillary tube coated with polyimide for mechanical strength through which the sample components...
01:08Electrodeposition
Electrodeposition is a technique used to separate an analyte from interferents by electrochemical processes. Here, the analyte is a metal ion that can be deposited on an electrode immersed in the sample solution. The electrochemical setup consists of an anode and a cathode. When an electric current is applied to the setup, oxidation occurs at the anode. At the cathode, which consists of a large metal surface, metal ions undergo reduction and deposit onto the surface.
Electrodeposition can...
Electrodeposition can...