Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview
CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Parent and professional experiences of a clinical trial of prenatal and postnatal stem cell therapy for severe osteogenesis imperfecta.

European journal of human genetics : EJHG·2026
Same author

"If I go down, if I crumble, then everybody does" - identity crisis and emotional strain in parents of children with rare and undiagnosed conditions: a qualitative study.

Orphanet journal of rare diseases·2026
Same author

The costs of genomic newborn screening in England: A micro-costing analysis from the Generation Study.

Genetics in medicine : official journal of the American College of Medical Genetics·2026
Same author

Moving beyond good intentions: a qualitative study exploring healthcare professionals' perspectives on delivering equitable prenatal testing in the English NHS.

International journal for equity in health·2026
Same author

Fetal Sequencing: Lessons Learnt and Challenges Remaining.

Prenatal diagnosis·2026
Same author

Precision Antisense Oligonucleotide Therapy Amenability for Infantile Genetic Epilepsies.

JAMA neurology·2026

Related Experiment Video

Updated: May 16, 2026

FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Non-invasive prenatal testing for single gene disorders: exploring the ethics.

Zuzana Deans1, Melissa Hill, Lyn S Chitty

  • 1Department of Community Based Medicine, Centre for Ethics in Medicine, University of Bristol, Bristol, UK.

European Journal of Human Genetics : EJHG
|November 29, 2012
PubMed
Summary

Non-invasive prenatal testing for single gene disorders offers early, safe genetic screening. Ethical considerations regarding autonomy, privacy, and fairness must be addressed before widespread clinical use.

More Related Videos

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Related Experiment Videos

Last Updated: May 16, 2026

FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Area of Science:

  • Reproductive Genetics
  • Bioethics
  • Prenatal Diagnostics

Background:

  • Non-invasive prenatal testing (NIPT) for single gene disorders is emerging as a significant advancement in prenatal care.
  • This technology provides safe and early testing options during pregnancy, offering substantial clinical benefits.
  • Widespread implementation necessitates a thorough examination of potential ethical implications.

Purpose of the Study:

  • To explore the ethical considerations surrounding non-invasive prenatal testing for single gene disorders.
  • To analyze potential conflicts with ethical principles such as respect for autonomy, privacy, and fairness.
  • To inform policy and guidelines for the responsible integration of NIPT in prenatal care.

Main Methods:

  • Presentation and analysis of four hypothetical scenarios.
  • Examination of ethical ideals in the context of NIPT for single gene disorders.
  • Discussion of potential impacts on clinical practice and patient autonomy.

Main Results:

  • Scenario 1: Highlights the tension between 'information only' testing and societal resource allocation.
  • Scenario 2: Illustrates how test simplicity may enhance autonomy but also increase uptake pressure.
  • Scenario 3: Warns of potential routinization, undermined informed consent, and vulnerability of newly diagnosed carriers.
  • Scenario 4: Introduces potential conflicts between a woman's and her partner's moral rights.

Conclusions:

  • Non-invasive prenatal testing for single gene disorders presents complex ethical challenges.
  • Careful consideration of autonomy, privacy, and fairness is crucial for ethical implementation.
  • Findings have implications for developing future policies and guidelines for prenatal care.