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Published on: March 16, 2017
Thiol-inducible direct fluorescence monitoring of drug release
Jun Wu1, Rong Huang, Changcheng Wang
1College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Hubei, Wuhan, 430072, PR China.
Organic & Biomolecular Chemistry
|November 29, 2012
Abstract:
A new bifunctional compound NCC, which undergoes thiol-mediated disulfide cleavage after cell entry, produces a red-shifted fluorescent emission in the cytosol and releases free active DNA alkylating agent CLB into the nucleus, and finally leads to DNA damage and cell death.

