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Label-Free Imaging of Single Proteins Secreted from Living Cells via iSCAT Microscopy
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Single beam grating coupled interferometry: high resolution miniaturized label-free sensor for plate based parallel

Daniel Patko1, Kaspar Cottier, Andras Hamori

  • 1Research Institute for Technical Physics and Material Science MFA Hungarian Academy of Sciences, H-1120 Konkoly-Thege út 29-33, Budapest, Hungary.

Optics Express
|November 29, 2012
PubMed
Summary
This summary is machine-generated.

A novel Grating Coupled Interferometry (GCI) sensor enhances sensing length control and enables multiplexing. This stable, symmetrical design uses a single laser beam for efficient, parallel sensing channel integration.

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Area of Science:

  • Photonics
  • Optical Sensing
  • Waveguide Technology

Background:

  • Interferometric sensors offer high sensitivity but often face challenges in precise control of sensing length and multiplexing capabilities.
  • Existing designs may require complex interrogation setups and can be limited in parallel channel integration.

Purpose of the Study:

  • To introduce and characterize a novel Grating Coupled Interferometry (GCI) sensor.
  • To enhance precise control over the sensing length and enable plate-based multiplexing.
  • To develop a stable and efficient platform for parallel sensing channel integration.

Main Methods:

  • Utilizing high-quality waveguides with dual incoupling and single outcoupling grating areas.
  • Employing a single expanded laser beam to simultaneously interrogate both incoupling gratings.
  • Implementing a phase modulation technique using a laterally divided two-cell liquid crystal modulator.
  • Demonstrating device characteristics for both TE and TM polarized modes.

Main Results:

  • Achieved increased and precisely controlled sensing length.
  • Demonstrated suitability for plate-based multiplexing.
  • Developed a highly symmetrical interferometric arrangement for enhanced stability.
  • Showcased straightforward integration of parallel sensing channels.
  • Validated performance for both TE and TM polarized modes.

Conclusions:

  • The developed GCI sensor offers a robust and versatile platform for advanced optical sensing applications.
  • The design facilitates efficient multiplexing and stable, parallel sensing.
  • This approach advances waveguide-based interferometry for diverse sensing needs.