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Related Experiment Video

Updated: May 16, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

Published on: June 8, 2017

Malaria and the heart.

Smitha Bhat¹, Jayaprakash Alva, Krithika Muralidhara

¹Department of Medicine, Father Muller Medical College, Mangalore, Karnataka, India. doctorsmitha@yahoo.co.in

BMJ Case Reports

|November 29, 2012

Summary

Plasmodium vivax malaria can cause acute coronary syndrome, presenting as chest pain and ECG changes. Prompt treatment of malaria and cardiac symptoms led to patient recovery.

Area of Science:

Cardiology
Infectious Diseases
Medical Research

Background:

Plasmodium vivax malaria is endemic in many regions.
Atherosclerotic coronary vascular disease risk factors were absent in this patient.
Manual laborers in endemic areas may be at risk.

Observation:

A 40-year-old presented with malaria symptoms including fever, chills, rigors, tachypnea, and icterus.
Peripheral smear confirmed Plasmodium vivax infection and thrombocytopenia.
The patient developed severe substernal chest pain six hours after artesunate treatment.

Findings:

ECG showed ST elevations in leads I, II, and aVL.
Elevated Troponin T and creatine kinase MB indicated myocardial injury.
Echocardiogram revealed left ventricle lateral wall hypokinesia.

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Hypoglycemia (blood sugar 49 mg%) was noted and corrected.

Implications:

This case highlights a rare presentation of acute coronary syndrome (ACS) potentially triggered by Plasmodium vivax malaria or its treatment.
Early recognition and management of both malaria and ACS are crucial for favorable outcomes.
Further research is needed to understand the pathophysiology linking malaria to cardiac events.