Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

Peripheral Artery Disease I: Introduction

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Research prioritization in paediatric orthopaedics and the impact on funding.

The bone & joint journal·2024

Same author

Utilizing speech analysis to differentiate progressive supranuclear palsy from Parkinson's disease.

Parkinsonism & related disorders·2023

Same author

The role of outpatient needle arthroscopy in the diagnosis and management of musculoskeletal complaints: A systematic review of the Arthrex NanoScope.

The Knee·2023

Same author

Moving orthopaedic procedures out of the operating theatre:Outpatient needle arthroscopy can reduce cost & waste, and increase inpatient capacity compared to conventional knee arthroscopy.

The Knee·2023

Same author

Is immobilisation required for toddler's fracture of the tibia?

BMJ (Clinical research ed.)·2022

Same author

Probing the self-assembly and anti-glioblastoma efficacy of a cinnamoyl-capped dipeptide hydrogelator.

Organic & biomolecular chemistry·2022

Same journal

The treatment of complex tibial shaft fractures by the Ilizarov method.

The Journal of bone and joint surgery. British volume·2012

Same journal

Posterior spinal arthrodesis for adolescent idiopathic scoliosis using pedicle screw instrumentation: does a bilateral or unilateral screw technique affect surgical outcome?

The Journal of bone and joint surgery. British volume·2012

Same journal

Anterior deltoid deficiency in reverse total shoulder replacement: a biomechanical study with cadavers.

The Journal of bone and joint surgery. British volume·2012

Same journal

Long-term results of dorsal intercarpal ligament capsulodesis for the treatment of chronic scapholunate instability.

The Journal of bone and joint surgery. British volume·2012

Same journal

Medial patellofemoral ligament reconstruction for patellar instability in patients with hypermobility: a case control study.

The Journal of bone and joint surgery. British volume·2012

Same journal

Total meniscectomy in adolescents: a 40-year follow-up.

The Journal of bone and joint surgery. British volume·2012

See all related articles

Search research articles

Related Experiment Video

Updated: May 16, 2026

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

Comorbidities in Perthes' disease: a case control study using the General Practice Research database.

D C Perry¹, C E Bruce, D Pope

¹Alder Hey Children's Hospital, Orthopaedic Department, Eaton Road, Liverpool L12 2AP, UK. danperry@doctors.org.uk

The Journal of Bone and Joint Surgery. British Volume

|November 29, 2012

Summary

This summary is machine-generated.

Perthes disease, a juvenile hip condition, is linked to congenital genitourinary and inguinal anomalies. Asthma also increases risk, suggesting potential intra-uterine factors in its unknown etiology.

More Related Videos

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse (POP) Quantification System

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse (POP) Quantification System

Published on: September 20, 2018

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Related Experiment Videos

Last Updated: May 16, 2026

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse (POP) Quantification System

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse (POP) Quantification System

Published on: September 20, 2018

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Area of Science:

Pediatric Orthopedics
Epidemiology
Genetics

Background:

Perthes disease is a childhood hip disorder involving osteonecrosis with an unknown cause.
Previous studies suggest comorbid associations, but their validity remains unclear.

Purpose of the Study:

To investigate associations between Perthes disease and previously suggested comorbid conditions.
To explore potential etiological insights through case-control analysis.

Main Methods:

A case-control study utilized the United Kingdom General Practice Research database.
Included 619 cases of Perthes disease and 2544 controls.
Investigated associations with congenital anomalies, behavioral disorders, and asthma.

Main Results:

Significantly increased risk of Perthes disease associated with hypospadias (OR 4.04), undescended testis (OR 1.83), and inguinal hernia (OR 1.79).
Generalized behavioral disorder showed an association (OR 1.55), but attention deficit hyperactivity disorder did not (OR 1.01).
Asthma significantly increased risk (OR 1.44), independent of steroid use.

Conclusions:

Perthes disease shows significant associations with congenital genitourinary and inguinal anomalies.
Findings suggest intra-uterine factors may play a critical role in Perthes disease causation.
Further research into comorbid associations can refine etiological theories.