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Published on: February 7, 2018
[Correlationship between chemokines and oxidative stress in chronic hepatitis B]
Jing-Wei Wang1, Li-Yuan Wang, Zhen-Hua Zhao
1Department of Infection, Linyi People's Hospital, Linyi 276003, China.
Objective:
The aim of this study is to investigate the possible associations of chemokines IP-10, Rantes and oxidative stress in chronic hepatits B (CHB).
Methods:
70 CHB patients and 10 healthy controls were enrolled in the study. Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of IFN-gamma-inducible protein-10 (IP-10) and regulated on activation normal T-cell-expressed and secreted (Rantes) and oxidative stress parameters (glutathione, GSH; glutathione disulfide, GSSG). Correlationship were analyzed by Spearman's rank correlation.
Result:
The levels of IP-10 and Rantes were higher in CHB patients than healthy controls, and strong positive associations were found between IP-10/Rantes and alanine aminotransferase (ALT). The levels of GSH and GSH/GSSG were lower in CHB patients than healthy controls, and GSH and GSH/GSSG were negatively correlated with ALT. The levels of IP-10 and Rantes were negatively correlated with GSH and GSH/GSSG respectively.
Conclusion:
Strong associations were found between chemokines and oxidative stress which participated in the pathogenesis of CHB.
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