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Oxindole derivatives: synthesis and antiglycation activity

Khalid Mohammed Khan1, Momin Khan, Nida Ambreen

  • 1H.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. khalid.khan@iccs.edu

Medicinal Chemistry (Shariqah (United Arab Emirates))
|November 30, 2012
PubMed
Summary

New oxindole derivatives were synthesized and tested for antiglycation activity. Compound 3-[(3-Chlorophenyl)methylidene]-1,3-dihydro-2H-indol-2-one demonstrated potent inhibition of protein glycation, outperforming the standard rutin.

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