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Related Experiment Video

Updated: May 16, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Pathophysiology of migraine.

Daniela Pietrobon¹, Michael A Moskowitz

¹Department of Biomedical Sciences, University of Padova, Padova, Italy. daniela.pietrobon@unipd.it

Annual Review of Physiology

|November 30, 2012

Summary

Migraine involves complex neurological interactions, not just blood vessels. Emerging research highlights the brain

Area of Science:

Neurology
Neuroscience
Neurobiology

Background:

Migraine was once thought to be solely a vascular disorder.
Current understanding implicates complex neurological interactions in migraine attacks.
The trigeminovascular system and cerebral cortex are key components.

Purpose of the Study:

To review emerging concepts in migraine science.
To explore mechanistic and therapeutic directions in migraine research.

Main Methods:

Review of in vivo and in vitro technologies.
Analysis of scientific literature on migraine mechanisms.

Main Results:

Cortical spreading depression and trigeminovascular system activation are significant.

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Published on: June 2, 2014

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

Published on: May 16, 2022

Neuronal and glial ion channels and transporters play a role.

A cortical excitatory/inhibitory imbalance may predispose individuals to migraine.

Conclusions:

Migraine is a complex neurological condition involving central and peripheral nervous systems.
Advances in technology reveal key molecular and cellular players.
New insights offer potential for novel therapeutic strategies.