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Updated: May 16, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Congenital factor II deficiency: moroccan cases.

S Imane1, Z Laalej, S Faez

  • 1Laboratory of Haematology, Ibn Rochd University Hospital, Casablanca, Morocco. Smyeji@yahoo.fr

International Journal of Laboratory Hematology
|November 30, 2012
PubMed
Summary
This summary is machine-generated.

Inherited factor II deficiency, a rare blood clotting disorder, requires coagulation tests for diagnosis. Prompt identification and treatment with fresh frozen plasma are crucial for managing severe bleeding risks.

Keywords:
Factor IIcoagulationcoagulopathycongenitaldeficiencyprothrombin

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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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07:26

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Published on: June 29, 2015

Area of Science:

  • Hematology
  • Genetics

Background:

  • Clotting factor II (prothrombin) is vital for blood coagulation.
  • Inherited factor II deficiency is a rare, autosomal recessive disorder with variable clinical presentations.
  • Diagnosis relies heavily on coagulation testing.

Observation:

  • Four cases of factor II deficiency were identified.
  • Patients ranged from 3 days to 40 years old.
  • Consanguinity was noted in all patient families.

Findings:

  • Factor II enzymatic activity was severely reduced (1-5%) in affected individuals.
  • Three patients presented with bleeding symptoms; one had an incidental finding.
  • Fresh frozen plasma transfusions were administered for treatment.

Implications:

  • Congenital factor II deficiency is a rare inherited condition.
  • Coagulation tests are essential for accurate diagnosis.
  • Prognosis and treatment access are linked to severe bleeding risks.